The Mathematical Institute, University of Oxford, Eprints Archive

On the proportion of cancer stem cells in a tumour

Johnston, M. D. and Maini, P. K. and Chapman, S. J. and Edwards, C. M. and Bodmer, W. F. (2010) On the proportion of cancer stem cells in a tumour. Journal of Theoretical Biology , 266 (4). pp. 708-711.

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Abstract

It is now generally accepted that cancers contain a sub-population, the cancer stem cells (CSCs), which initiate and drive a tumour’s growth. At least until recently it has been widely assumed that only a small proportion of the cells in a tumour are CSCs. Here we use a mathematical model, supported by experimental evidence, to show that such an assumption is unwarranted. We show that CSCs may comprise any possible proportion of the tumour, and that the higher the proportion the more aggressive the tumour is likely to be.

Item Type:Article
Uncontrolled Keywords:Cancer progression; Mathematical model; Feedback
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:968
Deposited By:Philip Maini
Deposited On:16 Sep 2010 07:51
Last Modified:08 Oct 2012 14:15

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