The Mathematical Institute, University of Oxford, Eprints Archive

Modelling chemotherapy resistance in palliation and failed cure

Monro, H C and Gaffney, E. A. (2009) Modelling chemotherapy resistance in palliation and failed cure. Journal of Theoretical Biology, 257 (2). pp. 292-302.

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Abstract

The goal of palliative cancer chemotherapy treatment is to prolong survival and improve quality of life when tumour eradication is not feasible. Chemotherapy protocol design is considered in this context using a simple, robust, model of advanced tumour growth with Gompertzian dynamics, taking into account the effects of drug resistance. It is predicted that reduced chemotherapy protocols can readily lead to improved survival times due to the effects of competition between resistant and sensitive tumour cells. Very early palliation is also predicted to quickly yield near total tumour resistance and thus decrease survival duration. Finally, our simulations indicate that failed curative attempts using dose densification, a common protocol escalation strategy, can reduce survival times.

Item Type:Article
Uncontrolled Keywords: Mathematical modelling; Drug resistance; Drug scheduling; Advanced cancer; Survival time
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:883
Deposited By:Eamonn Gaffney
Deposited On:14 Jan 2010 07:54
Last Modified:13 Mar 2011 11:48

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