Tindall, M. J. and Porter, S. L. and Wadhams, G H and Maini, P. K. and Armitage, J. P. (2009) Spatiotemporal modelling of CheY complexes in escherichia coli chemotaxis. Progress in Biophysics Molecular Biology, 100 (1-3). pp. 40-46.
The chemotaxis pathway of Escherichia coli is one of the best studied and modelled biological signalling pathways. Here we extend existing modelling approaches by explicitly including a description of the formation and subcellular localization of intermediary complexes in the phosphotransfer pathway. The inclusion of these complexes shows that only about 60% of the total output response regulator (CheY) is uncomplexed at any moment and hence free to interact with its target, the flagellar motor. A clear strength of this model is its ability to predict the experimentally observable subcellular localization of CheY throughout a chemotactic response. We have found good agreement between the model output and experimentally determined CheY localization patterns.
|Uncontrolled Keywords:||Bacterial chemotaxis; Phosphotransfer; Complex formation; Spatiotemporal mathematical modelling; Signal transduction|
|Subjects:||A - C > Biology and other natural sciences|
|Research Groups:||Centre for Mathematical Biology|
|Deposited By:||Philip Maini|
|Deposited On:||19 Nov 2009 15:58|
|Last Modified:||19 Nov 2009 16:23|
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