Smallbone, K. and Gatenby, R. A. and Maini, P. K. (2008) Mathematical modelling of tumour acidity. Journal of Theoretical Biology, 255 (1). pp. 106-112.
Acid-mediated tumour invasion is receiving increasing experimental and clinical attention. Previous models proposed to describe this phenomenon failed to capture key properties of the system, such as the existence of the benign steady state, or predicted incorrectly the size of the inter-tissue gap. Here we show that taking proper account of quiescence ameliorates these drawbacks as well as revealing novel behaviour. The simplicity of the model allows us to fully identify the key parameters controlling different aspects of behaviour.
|Uncontrolled Keywords:||Tumour invasion; Glycolytic phenotype; Acidity; Mathematical modelling|
|Subjects:||A - C > Biology and other natural sciences|
|Research Groups:||Centre for Mathematical Biology|
|Deposited By:||Philip Maini|
|Deposited On:||14 Oct 2008|
|Last Modified:||29 May 2015 18:27|
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