The Mathematical Institute, University of Oxford, Eprints Archive

Overview of mathematical approaches used to model bacterial chemotaxis I: the single cell

Tindall, M. J. and Porter, S. L. and Maini, P. K. and Gaglia, G. and Armitage, J. P. (2008) Overview of mathematical approaches used to model bacterial chemotaxis I: the single cell. Bulletin of Mathematical Biology, 70 (6). pp. 1525-1569.

[img]
Preview
PDF
580Kb

Abstract

Mathematical modeling of bacterial chemotaxis systems has been influential and insightful in helping to understand experimental observations. We provide here a comprehensive overview of the range of mathematical approaches used for modeling, within a single bacterium, chemotactic processes caused by changes to external gradients in its environment. Specific areas of the bacterial system which have been studied and modeled are discussed in detail, including the modeling of adaptation in response to attractant gradients, the intracellular phosphorylation cascade, membrane receptor clustering, and spatial modeling of intracellular protein signal transduction. The importance of producing robust models that address adaptation, gain, and sensitivity are also discussed. This review highlights that while mathematical modeling has aided in understanding bacterial chemotaxis on the individual cell scale and guiding experimental design, no single model succeeds in robustly describing all of the basic elements of the cell. We conclude by discussing the importance of this and the future of modeling in this area.

Item Type:Article
Additional Information:n/a
Uncontrolled Keywords:Bacterial chemotaxis - Single cell - Review
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:726
Deposited By:Philip Maini
Deposited On:18 Aug 2008
Last Modified:20 Jul 2009 14:23

Repository Staff Only: item control page