van Leeuwen, I. M. M. and Byrne, H. M. and Johnston, M. D. and Edwards, C. M. and Chapman, S. J. and Bodmer, W. F. and Maini, P. K. (2008) Modelling multiscale aspects of colorectal cancer. AIP Conference Proceedings, 971 (1). pp. 3-7.
Colorectal cancer (CRC) is responsible for nearly half a million deaths annually world-wide . We present a series of mathematical models describing the dynamics of the intestinal epithelium and the kinetics of the molecular pathway most commonly mutated in CRC, the Wnt signalling network. We also discuss how we are coupling such models to build a multiscale model of normal and aberrant guts. This will enable us to combine disparate experimental and clinical data, to investigate interactions between phenomena taking place at different levels of organisation and, eventually, to test the efficacy of new drugs on the system as a whole.
|Uncontrolled Keywords:||cancer, modelling, reaction kinetics, cellular biophysics|
|Subjects:||A - C > Biology and other natural sciences|
|Research Groups:||Centre for Mathematical Biology|
|Deposited By:||Philip Maini|
|Deposited On:||29 Apr 2008|
|Last Modified:||20 Jul 2009 14:23|
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