Addison-Smith, B. and McElwain, D. L. S. and Maini, P. K. (2008) A simple mechanistic model of sprout spacing in tumour-associated angiogenesis. Journal of Theoretical Biology, 250 (1). pp. 1-15.
This paper develops a simple mathematical model of the siting of capillary sprouts on an existing blood vessel during the initiation of tumour-induced angiogenesis. The model represents an inceptive attempt to address the question of how unchecked sprouting of the parent vessel is avoided at the initiation of angiogenesis, based on the idea that feedback regulation processes play the dominant role. No chemical interaction between the proangiogenic and antiangiogenic factors is assumed. The model is based on corneal pocket experiments, and provides a mathematical analysis of the initial spacing of angiogenic sprouts.
|Uncontrolled Keywords:||Angiogenesis; Mathematical model; Inhibitor; VEGF; Endostatin|
|Subjects:||A - C > Biology and other natural sciences|
|Research Groups:||Centre for Mathematical Biology|
|Deposited By:||Philip Maini|
|Deposited On:||17 Jan 2008|
|Last Modified:||20 Jul 2009 14:23|
Repository Staff Only: item control page