The Mathematical Institute, University of Oxford, Eprints Archive

Travelling gradients in interacting morphogen systems

Baker, Ruth E. and Maini, P. K. (2007) Travelling gradients in interacting morphogen systems. Mathematical Biosciences, 209 (1). pp. 30-50.

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Abstract

Morphogen gradients are well known to play several important roles in development; however the mechanisms underlying the formation and maintenance of these gradients are often not well understood. In this work, we investigate whether the presence of a secondary morphogen can increase the robustness of the primary morphogen gradient to perturbation, thereby providing a more stable mechanism for development. We base our model around the interactions of Fibroblast Growth Factor 8 and retinoic acid, which have been shown to act as morphogens in many developmental systems. In particular, we investigate the formation of opposing gradients of these morphogens along the antero-posterior axis of vertebrate embryos, thereby controlling temporal and spatial aspects of axis segmentation and neuronal differentiation.

Item Type:Article
Additional Information:n/a
Uncontrolled Keywords:Morphogen gradients; Mathematical modelling; FGF8; Retinoic acid; Segmentation
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:642
Deposited By:Philip Maini
Deposited On:17 Aug 2007
Last Modified:20 Jul 2009 14:23

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