Baker, Ruth E. and Maini, P. K. (2007) Travelling gradients in interacting morphogen systems. Mathematical Biosciences, 209 (1). pp. 30-50.
Morphogen gradients are well known to play several important roles in development; however the mechanisms underlying the formation and maintenance of these gradients are often not well understood. In this work, we investigate whether the presence of a secondary morphogen can increase the robustness of the primary morphogen gradient to perturbation, thereby providing a more stable mechanism for development. We base our model around the interactions of Fibroblast Growth Factor 8 and retinoic acid, which have been shown to act as morphogens in many developmental systems. In particular, we investigate the formation of opposing gradients of these morphogens along the antero-posterior axis of vertebrate embryos, thereby controlling temporal and spatial aspects of axis segmentation and neuronal differentiation.
|Uncontrolled Keywords:||Morphogen gradients; Mathematical modelling; FGF8; Retinoic acid; Segmentation|
|Subjects:||A - C > Biology and other natural sciences|
|Research Groups:||Centre for Mathematical Biology|
|Deposited By:||Philip Maini|
|Deposited On:||17 Aug 2007|
|Last Modified:||20 Jul 2009 14:23|
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