The Mathematical Institute, University of Oxford, Eprints Archive

Structural adaptation in normal and cancerous vasculature

Maini, P. K. and Alarcon, T. and Byrne, H. M. and Owen, M. R. and Murphy, J. (2007) Structural adaptation in normal and cancerous vasculature. In: In: MathEverywhere: Deterministic and Stochastic Modelling in Biomedicine, Economics and Industry. Springer, Berlin, Germany, pp. 165-178. ISBN 3-540-44445-9

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Abstract

The dynamics of cancerous tissue growth involves the complex interaction of a number of phenomena interacting over a range of temporal and spatial scales. While several processes involved have been studied, the adaptation of the vasculature within a growing tumour has thus far received little attention. We consider a hybrid cellular automaton model which analyses the interaction between the tumour vascular network and tissue growth. We compute the temporal behaviour of the cancerous cell population under different hypotheses of structural adaptation in the vasculature. This may provide a possible method of determining experimentally which adaptation mechanisms are at work.

Item Type:Book Section
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:580
Deposited By:Philip Maini
Deposited On:25 Mar 2007
Last Modified:20 Jul 2009 14:22

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