The Mathematical Institute, University of Oxford, Eprints Archive

A model for chondrogenic condensations in the developing limb

Oster, G. F. and Murray, J. D. and Maini, P. K. (1985) A model for chondrogenic condensations in the developing limb. Journal of Embryology and experimental Morphology, 89 . pp. 93-112.

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Abstract

The hyaluronate component of the extracellular matrix is a powerfully hydrophilic polymer, capable of osmotically swelling and deswelling by a volume factor of 5 or more. At the time of cartilage condensation in the limb bud the chondrocytes start to produce hyaluronidase, an enzyme which degrade hyaluronate. The consequent deswelling brings the chondrocytes closer together - close enough for intercellular cell tractions to become effective and intercellular junctions to form. By analysing the physiochemical situation we show how these processes, principally the coupling of the osmotic deswelling with cellular traction forces, can produce cartilage condensation patterns resembling those in the early limb bud. In distinction from our earlier model for chondrogenic condensations this mechanism does not depend on cell motions other than convective transport by contraction.

Item Type:Article
Uncontrolled Keywords:chondrogenesis, extracellular matrix, cell traction, limb, model
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:533
Deposited By:Philip Maini
Deposited On:15 Dec 2006
Last Modified:20 Jul 2009 14:22

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