The Mathematical Institute, University of Oxford, Eprints Archive

On the kinetics of suicide substrates

Burke, M. A. and Maini, P. K. and Murray, J. D. (1990) On the kinetics of suicide substrates. Biophysical Chemistry, 37 (1-3). pp. 81-90.

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Abstract

We consider a realistic suicide substrate reaction which can be represented by four rate equations for the concentrations of the various molecules as functions of time. We present a general procedure to obtain accurate, approximate solutions analytically in terms of the rate equation parameters. This systematic technique provides more accurate approximations to the exact (numerical) solutions than other approximate methods which have been proposed based on a pseudo-steady state hypothesis.

Item Type:Article
Uncontrolled Keywords:Suicide substrate; Enzyme kinetic model; Approximate solution technique; Enzyme targeting
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:521
Deposited By:Philip Maini
Deposited On:15 Dec 2006
Last Modified:08 Oct 2012 09:45

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