Burke, M. A. and Maini, P. K. and Murray, J. D. (1990) On the kinetics of suicide substrates. Biophysical Chemistry, 37 (1-3). pp. 81-90.
We consider a realistic suicide substrate reaction which can be represented by four rate equations for the concentrations of the various molecules as functions of time. We present a general procedure to obtain accurate, approximate solutions analytically in terms of the rate equation parameters. This systematic technique provides more accurate approximations to the exact (numerical) solutions than other approximate methods which have been proposed based on a pseudo-steady state hypothesis.
|Uncontrolled Keywords:||Suicide substrate; Enzyme kinetic model; Approximate solution technique; Enzyme targeting|
|Subjects:||A - C > Biology and other natural sciences|
|Research Groups:||Centre for Mathematical Biology|
|Deposited By:||Philip Maini|
|Deposited On:||15 Dec 2006|
|Last Modified:||29 May 2015 18:23|
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