Burke, M. A. and Maini, P. K. and Murray, J. D. (1993) Suicide substrate reaction-diffusion equations: varying the source. Journal of Mathematics Applied Medicine & Biology, 10 (2). pp. 97-114.
The suicide substrate reaction is a model for certain enzyme-inhibiting drugs. This reaction system is examined assuming that the substrate diffuses freely while the enzyme remains fixed. Two sets of initial and boundary conditions are examined: one modelling an instantaneous point source, akin to an injection of substrate, the other, a continuous point source, akin to a continuing influx, or intravenous drip, of substrate. The quasi-steady-state assumption is applied to obtain analytical solutions for a limited parameter space. Finally, further applications of numerical and analytical experimentation on pharmaceutical mechanisms are described.
|Uncontrolled Keywords:||suicide substrate • reaction-diffusion equations • analytical solution • quasi-steady-state assumption • instantaneous point source • continuous point source|
|Subjects:||A - C > Biology and other natural sciences|
|Research Groups:||Centre for Mathematical Biology|
|Deposited By:||Philip Maini|
|Deposited On:||12 Dec 2006|
|Last Modified:||20 Jul 2009 14:21|
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