The Mathematical Institute, University of Oxford, Eprints Archive

Rhythmic firing patterns in SCN: The role of circuit interactions

Zhang, L. and Aguilar-Roblero, R. and Barrio, R. A. and Maini, P. K. (1995) Rhythmic firing patterns in SCN: The role of circuit interactions. International Journal of Bio-Medical Computing, 38 (1). pp. 23-31.



The suprachiasmatic nucleus (SCN) is believed to contain the main generator of circadian rhythmicity in mammals. In order to obtain further functional details of this, electrophysiological extracellular measurements in vitro were made. By means of an interspike interval distribution analysis, it is shown that there is a novel kind of neuronal firing pattern: the harmonic pattern. From these observations, we have developed a theoretical model based on possible filtering processes occurring during synaptic transmission. The model suffices to infer that regular ultradian oscillators could be an emergent property of circuit interactions of cells in the suprachiasmatic nucleus.

Item Type:Article
Uncontrolled Keywords:Rhythms; Suprachiasmatic nucleus; Electrophysiology; Model
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:486
Deposited By: Philip Maini
Deposited On:10 Dec 2006
Last Modified:29 May 2015 18:23

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