The Mathematical Institute, University of Oxford, Eprints Archive

A mathematical model for collagen fibre formation during foetal and adult dermal wound healing

Dale, P. D. and Sherratt, J. A. and Maini, P. K. (1996) A mathematical model for collagen fibre formation during foetal and adult dermal wound healing. Proceedings of the Royal Society London B, 263 (1370). pp. 653-660. ISSN 0962-8452 (Paper) 1471-2954

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Abstract

Adult dermal wounds, in contrast to foetal wounds, heal with the formation of scar tissue. A crucial factor in determining the nature of the healed tissue is the ratio of collagen 1 to collagen 3, which regulates the diameter of collagen fibres. We develop a mathematical model which focuses on the stimulus for collagen synthesis due to the secretion of the different isoforms of the regulatory chemical transforming growth factor $\beta $. Numerical simulations of the model lead to a value of this ratio consistent with that of healthy tissue for the foetus but corresponding to scarring in adult wound healing. We investigate the effect of topical application of TGF$\beta $ isoforms during healing and determine the key parameters which control the difference between adult and foetal repair.

Item Type:Article
Uncontrolled Keywords:n/a
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:461
Deposited By:Philip Maini
Deposited On:06 Dec 2006
Last Modified:20 Jul 2009 14:21

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