Gaffney, E. A. and Maini, P. K. and Sherratt, J. A. and Dale, P. D. (1997) Wound healing in the corneal epithelium: biological mechanisms and mathematical models. Journal of Theoretical Medicine, 1 (1). pp. 13-23.
Corneal epithelium has a highly specialised wound-healing response. The biological aspects of this repair process are reviewed, and methods of modelling it mathematically are described. A model which focuses on the source of epidermal growth factor (EGF) within a healing wound is described. By considering mathematical representations of a number of possible source terms, it is shown that the EGF present in the tear film is insufficient to explain the observed rate of healing, and experimental approaches are suggested for distinguishing between other sources. Also, the simulation of exogenous addition of EGF using the model is described. An issue that has been the subject of considerable debate in the literature is the role of eyeball curvature. The mode is used to show that this curvature is not significant for either the speed or form of healing in the epithelium. In conclusion, a comparison is made between wound healing in the corneal epithelium with that in the epidermis of the skin. Possible directions for future modelling work are considered.
|Uncontrolled Keywords:||Biomathematical modelling, corneal epithelium|
|Subjects:||A - C > Biology and other natural sciences|
|Research Groups:||Centre for Mathematical Biology|
|Deposited By:||Philip Maini|
|Deposited On:||06 Dec 2006|
|Last Modified:||20 Jul 2009 14:21|
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