The Mathematical Institute, University of Oxford, Eprints Archive

Mathematical modelling of extracellular matrix dynamics using discrete cells: Fiber orientation and tissue regeneration

Dallon, J. C. and Sherratt, J. A. and Maini, P. K. (1999) Mathematical modelling of extracellular matrix dynamics using discrete cells: Fiber orientation and tissue regeneration. Journal of Theoretical Biology, 199 (4). pp. 449-471.

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Abstract

Matrix orientation plays a crucial role in determining the severity of scar tissue after dermal wounding. We present a model framework which allows us to examine the interaction of many of the factors involved in orientation and alignment. Within this framework, cells are considered as discrete objects, while the matrix is modelled as a continuum. Using numerical simulations, we investigate the effect on alignment of changing cell properties and of varying cell interactions with collagen and fibrin.

Item Type:Article
Uncontrolled Keywords:n/a
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:425
Deposited By:Philip Maini
Deposited On:23 Nov 2006
Last Modified:08 Oct 2012 12:43

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