Collier, J. R. and McInerney, D. and Schnell, S. and Maini, P. K. and Gavaghan, D. J. and Houston, P. and Stern, C. D. (2000) A cell cycle model for somitogenesis: mathematical formulation and numerical simulation. Journal of Theoretical Biology, 207 (3). pp. 305316.

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Abstract
After many years of research, the mechanisms that generate a periodic pattern of repeated elements (somites) along the length of the embryonic body axis is still one of the major unresolved problems in developmental biology. Here we present a mathematical formulation of the cell cycle model for somitogenesis proposed in Development105 (1989), 119–130. Somite precursor cells in the node are asynchronous, and therefore, as a population, generate continuously presomite cells which enter the segmental plate. The model makes the hypothesis that there exists a time window within the cell cycle, making up oneseventh of the cycle, which gates the presomite cells so that they make somites discretely, seven per cycle. We show that the model can indeed account for the spatiotemporal patterning of somite formation during normal development as well as the periodic abnormalities produced by heat shock treatment. We also relate the model to recent molecular data on the process of somite formation.
Item Type:  Article 

Uncontrolled Keywords:  n/a 
Subjects:  A  C > Biology and other natural sciences 
Research Groups:  Centre for Mathematical Biology 
ID Code:  409 
Deposited By:  Philip Maini 
Deposited On:  22 Nov 2006 
Last Modified:  29 May 2015 18:21 
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