Schnell, S. and Maini, P. K. (2002) *Enzyme kinetics far from the standard quasi-steady-state and equilibrium approximations.* Mathematical and Computer Modelling, 35 (1-2). pp. 137-144.

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## Abstract

Analytic approximations of the time-evolution of the single enzyme-substrate reaction are valid for all but a small region of parameter space in the positive initial enzyme-initial substrate concentration plane. We find velocity equations for the substrate decomposition and product formation with the aid of the total quasi-steady-state approximation and an aggregation technique for cases where neither the more normally employed standard nor reverse quasi-steady-state approximations are valid. Applications to determining reaction kinetic parameters are discussed.

Item Type: | Article |
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Uncontrolled Keywords: | Total quasi-steady-state approximation; Fitting procedure; Aggregation technique; Singular perturbation |

Subjects: | A - C > Biology and other natural sciences |

Research Groups: | Centre for Mathematical Biology |

ID Code: | 400 |

Deposited By: | Philip Maini |

Deposited On: | 20 Nov 2006 |

Last Modified: | 20 Jul 2009 14:21 |

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