Maini, P. K. and Olsen, L. and Sherratt, J. A. (2002) Mathematical models for cell-matrix interactions during dermal wound healing. International Journal of Bifurcation and Chaos, 12 (9). pp. 2021-2029.
This paper contains a review of our recent work on the mathematical modeling of cell interaction with extracellular matrix components during the process of dermal wound healing. The models are of partial differential equation type and allow us to investigate in detail how various mechanochemical effects may be responsible for certain wound healing disorders such as fibrocontractive and fibroproliferative diseases. We also present a model for wound healing angiogenesis. The latter has several features in common with angiogenesis during cancer tumour growth and spread so a deeper understanding of the phenomenon in the context of wound healing may also help in the treatment of certain cancers.
|Uncontrolled Keywords:||Wound contraction; fibroproliferative disorders; angiogenesis|
|Subjects:||A - C > Biology and other natural sciences|
|Research Groups:||Centre for Mathematical Biology|
|Deposited By:||Philip Maini|
|Deposited On:||17 Nov 2006|
|Last Modified:||29 May 2015 18:21|
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