Alarcon, T. and Byrne, H. M. and Maini, P. K. (2004) Towards whole-organ modelling of tumour growth. Progress in Biophysics and Molecular Biology, 85 (2-3). pp. 451-472.
Multiscale approaches to modelling biological phenomena are growing rapidly. We present here some recent results on the formulation of a theoretical framework which can be developed into a fully integrative model for cancer growth. The model takes account of vascular adaptation and cell-cycle dynamics. We explore the effects of spatial inhomogeneity induced by the blood flow through the vascular network and of the possible effects of p27 on the cell cycle. We show how the model may be used to investigate the efficiency of drug-delivery protocols.
|Uncontrolled Keywords:||Cancer; Vascular networks; Blood flow heterogeneity; Cell cycle; p27|
|Subjects:||A - C > Biology and other natural sciences|
|Research Groups:||Centre for Mathematical Biology|
|Deposited By:||Philip Maini|
|Deposited On:||16 Nov 2006|
|Last Modified:||20 Jul 2009 14:20|
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