The Mathematical Institute, University of Oxford, Eprints Archive

Towards whole-organ modelling of tumour growth

Alarcon, T. and Byrne, H. M. and Maini, P. K. (2004) Towards whole-organ modelling of tumour growth. Progress in Biophysics and Molecular Biology, 85 (2-3). pp. 451-472.



Multiscale approaches to modelling biological phenomena are growing rapidly. We present here some recent results on the formulation of a theoretical framework which can be developed into a fully integrative model for cancer growth. The model takes account of vascular adaptation and cell-cycle dynamics. We explore the effects of spatial inhomogeneity induced by the blood flow through the vascular network and of the possible effects of p27 on the cell cycle. We show how the model may be used to investigate the efficiency of drug-delivery protocols.

Item Type:Article
Uncontrolled Keywords:Cancer; Vascular networks; Blood flow heterogeneity; Cell cycle; p27
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:367
Deposited By: Philip Maini
Deposited On:16 Nov 2006
Last Modified:29 May 2015 18:20

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