The Mathematical Institute, University of Oxford, Eprints Archive

Extracellular volume regulation and growth

Hajek, D. and Kolar, P. and Maini, P. K. and Starha, P. (2005) Extracellular volume regulation and growth. Medical Hypotheses, 64 (2). pp. 303-306.



We have formalized extracellular and intracellular volume interaction with each other and the influence of these processes on the type of cell growth. The linearized model was verified by stereo metric solution and the results were compared with experimental data. Two theoretical solutions were found: Solution 1, extracellular volume (ECV) was calculated to be about 23% of total body volume (TV). Stereo metric solution suggested the cubic cell cluster formed by 8-cells. This hypothesis (Solution l) explains the ECV to be compatible with the widely accepted value (about 23% of TV). In addition, the 8-cell cluster hypothesis explains the existence of ECV oscillation with the period of about seven days. This hypothesis probably describes the dominant type of growth in humans. Solution 2, in this type of growth, ECV fills about 77% per cent of TV. Instead of the 8-cell cube, in this type of proliferation 4-cells could form a tetrahedron. This type of growth could be beneficial in processes where free space in tissue or organ must be filled for example in peptic ulcer healing and namely in repopulating of free space in a bone after high dose chemotherapy.

Item Type:Article
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:355
Deposited By: Philip Maini
Deposited On:10 Nov 2006
Last Modified:29 May 2015 18:20

Repository Staff Only: item control page