Ribba, B. and Marron, K. and Agur, Z. and Alarcon, T. and Maini, P. K. (2005) A mathematical model of Doxorubicin treatment efficacy on non-Hodgkin’s lymphoma: Investigation of current protocol through theoretical modelling results. Bulletin of Mathematical Biology, 67 (1). pp. 79-99.
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Abstract
Doxorubicin treatment outcomes for non-Hodgkin’s lymphomas (NHL) are mathematically modelled and computationally analyzed. The NHL model includes a tumor structure incorporating mature and immature vessels, vascular structural adaptation and NHL cell-cycle kinetics in addition to Doxorubicin pharmacokinetics (PK) and pharmacodynamics (PD). Simulations provide qualitative estimations of the effect of Doxorubicin on high-grade (HG), intermediate-grade (IG) and low-grade (LG) NHL. Simulation results imply that if the interval between successive drug applications is prolonged beyond a certain point, treatment will be inefficient due to effects caused by heterogeneous blood flow in the system.
| Item Type: | Article |
|---|---|
| Subjects: | A - C > Biology and other natural sciences |
| Research Groups: | Centre for Mathematical Biology |
| ID Code: | 352 |
| Deposited By: | Philip Maini |
| Deposited On: | 10 Nov 2006 |
| Last Modified: | 20 Jul 2009 14:20 |
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