Alarcon, T. and Byrne, H. M. and Maini, P. K. (2005) A multiple scale model for tumor growth. Multiscale Model Simulation, 3 (2). pp. 440-475.
We present a physiologically structured lattice model for vascular tumor growth which accounts for blood flow and structural adaptation of the vasculature, transport of oxygen, interaction between cancerous and normal tissue, cell division, apoptosis, vascular endothelial growth factor release, and the coupling between these processes. Simulations of the model are used to investigate the effects of nutrient heterogeneity, growth and invasion of cancerous tissue, and emergent growth laws.
|Uncontrolled Keywords:||blood flow heterogeneity; growth laws; physiologically structured lattice model; cell-cycle; p27; p53; multiple scales|
|Subjects:||A - C > Biology and other natural sciences|
|Research Groups:||Centre for Mathematical Biology|
|Deposited By:||Philip Maini|
|Deposited On:||10 Nov 2006|
|Last Modified:||20 Jul 2009 14:20|
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