The Mathematical Institute, University of Oxford, Eprints Archive

A multiple scale model for tumor growth

Alarcon, T. and Byrne, H. M. and Maini, P. K. (2005) A multiple scale model for tumor growth. Multiscale Model Simulation, 3 (2). pp. 440-475.

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Abstract

We present a physiologically structured lattice model for vascular tumor growth which accounts for blood flow and structural adaptation of the vasculature, transport of oxygen, interaction between cancerous and normal tissue, cell division, apoptosis, vascular endothelial growth factor release, and the coupling between these processes. Simulations of the model are used to investigate the effects of nutrient heterogeneity, growth and invasion of cancerous tissue, and emergent growth laws.

Item Type:Article
Uncontrolled Keywords:blood flow heterogeneity; growth laws; physiologically structured lattice model; cell-cycle; p27; p53; multiple scales
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:351
Deposited By:Philip Maini
Deposited On:10 Nov 2006
Last Modified:20 Jul 2009 14:20

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