Smallbone, K. and Gavaghan, D. J. and Gatenby, R. A. and Maini, P. K. (2005) The role of acidity in solid tumour growth and invasion. Journal of Theoretical Biology, 235 (4). pp. 476-484.
Acidic pH is a common characteristic of human tumours. It has a significant impact on tumour progression and response to therapies. In this paper, we develop a simple model of three-dimensional tumour growth to examine the role of acidosis in the interaction between normal and tumour cell populations. Both vascular and avascular tumour dynamics are investigated, and a number of different behaviours are observed. Whilst an avascular tumour always proceeds to a benign steady state, a vascular tumour may display either benign or invasive dynamics, depending on the value of a critical parameter. Analysis of the model allows us to assess novel therapies directed towards changing the level of acidity within the tumour.
|Uncontrolled Keywords:||Tumour invasion; Glycolytic phenotype; Acidity; Mathematical modelling|
|Subjects:||A - C > Biology and other natural sciences|
|Research Groups:||Centre for Mathematical Biology|
|Deposited By:||Philip Maini|
|Deposited On:||10 Nov 2006|
|Last Modified:||20 Jul 2009 14:20|
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