The Mathematical Institute, University of Oxford, Eprints Archive

Interpreting two-photon imaging data of lymphocyte motility

Meyer-Hermann, M. E. and Maini, P. K. (2005) Interpreting two-photon imaging data of lymphocyte motility. Physical Review E, 71 (6). 061912-1.



Recently, using two-photon imaging it has been found that the movement of B and T cells in lymph nodes can be described by a random walk with persistence of orientation in the range of 2 minutes. We interpret this new class of lymphocyte motility data within a theoretical model. The model considers cell movement to be composed of the movement of subunits of the cell membrane. In this way movement and deformation of the cell are correlated to each other. We find that, indeed, the lymphocyte movement in lymph nodes can best be described as a random walk with persistence of orientation. The assumption of motility induced cell elongation is consistent with the data. Within the framework of our model the two-photon data suggest that T and B cells are in a single velocity state with large stochastic width. The alternative of three different velocity states with frequent changes of their state and small stochastic width is less likely. Two velocity states can be excluded.

Item Type:Article
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:341
Deposited By: Philip Maini
Deposited On:10 Nov 2006
Last Modified:29 May 2015 18:20

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