The Mathematical Institute, University of Oxford, Eprints Archive

A mathematical investigation of a clock and wavefront model for somitogenesis

Baker, Ruth E. and Schnell, S. and Maini, P. K. (2006) A mathematical investigation of a clock and wavefront model for somitogenesis. Journal of Mathematical Biology, 52 (4). pp. 458-482.

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Abstract

Abstract Somites are transient blocks of cells that form sequentially along the antero-posterior axis of vertebrate embryos. They give rise to the vertebrae, ribs and other associated features of the trunk. In this work we develop and analyse a mathematical formulation of a version of the Clock and Wavefront model for somite formation, where the clock controls when the boundaries of the somites form and the wavefront determines where they form. Our analysis indicates that this interaction between a segmentation clock and a wavefront can explain the periodic pattern of somites observed in normal embryos. We can also show that a simplification of the model provides a mechanism for predicting the anomalies resulting from perturbation of the wavefront.

Item Type:Article
Uncontrolled Keywords:Somitogenesis - Clock and Wavefrontmodel - Segmentation clock - FGF8 wavefront - Travelling waves
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:334
Deposited By:Philip Maini
Deposited On:09 Nov 2006
Last Modified:20 Jul 2009 14:20

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