Baker, Ruth E. and Schnell, S. and Maini, P. K. (2006) A mathematical investigation of a clock and wavefront model for somitogenesis. Journal of Mathematical Biology, 52 (4). pp. 458482.

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Abstract
Abstract Somites are transient blocks of cells that form sequentially along the anteroposterior axis of vertebrate embryos. They give rise to the vertebrae, ribs and other associated features of the trunk. In this work we develop and analyse a mathematical formulation of a version of the Clock and Wavefront model for somite formation, where the clock controls when the boundaries of the somites form and the wavefront determines where they form. Our analysis indicates that this interaction between a segmentation clock and a wavefront can explain the periodic pattern of somites observed in normal embryos. We can also show that a simplification of the model provides a mechanism for predicting the anomalies resulting from perturbation of the wavefront.
Item Type:  Article 

Uncontrolled Keywords:  Somitogenesis  Clock and Wavefrontmodel  Segmentation clock  FGF8 wavefront  Travelling waves 
Subjects:  A  C > Biology and other natural sciences 
Research Groups:  Centre for Mathematical Biology 
ID Code:  334 
Deposited By:  Philip Maini 
Deposited On:  09 Nov 2006 
Last Modified:  29 May 2015 18:20 
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