The Mathematical Institute, University of Oxford, Eprints Archive

Mathematical models in physiology

Gavaghan, D. J. and Garny, A. and Maini, P. K. and Kohl, P. (2006) Mathematical models in physiology. Philosophical Transactions of the Royal Society A, 364 (1842). pp. 1099-1106.



Computational modelling of biological processes and systems has witnessed a remarkable development in recent years. The search-term (modelling OR modeling) yields over 58000 entries in PubMed, with more than 34000 since the year 2000: thus, almost two-thirds of papers appeared in the last 5–6 years, compared to only about one-third in the preceding 5–6 decades.

The development is fuelled both by the continuously improving tools and techniques available for bio-mathematical modelling and by the increasing demand in quantitative assessment of element inter-relations in complex biological systems. This has given rise to a worldwide public domain effort to build a computational framework that provides a comprehensive theoretical representation of integrated biological function—the Physiome.

The current and next issues of this journal are devoted to a small sub-set of this initiative and address biocomputation and modelling in physiology, illustrating the breadth and depth of experimental data-based model development in biological research from sub-cellular events to whole organ simulations.

Item Type:Article
Uncontrolled Keywords:physiome, quantitative biology, systems biology, theoretical biology, integrative physiology
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:333
Deposited By: Philip Maini
Deposited On:09 Nov 2006
Last Modified:29 May 2015 18:20

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