The Mathematical Institute, University of Oxford, Eprints Archive

An analysis of B cell selection mechanisms in germinal centres

Meyer-Hermann, M. E. and Maini, P. K. and Iber, D. (2006) An analysis of B cell selection mechanisms in germinal centres. Mathematical Medicine & Biology, 23 (3). pp. 255-277.

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Abstract

Affinity maturation of antibodies during immune responses is achieved by multiple rounds of somatic hypermutation and subsequent preferential selection of those B cells that express B cell receptors with improved binding characteristics for the antigen. The mechanism underlying B cell selection has not yet been defined. By employing an agent-based model, we show that for physiologically reasonable parameter values affinity maturation can be driven by competition for neither binding sites nor antigen—even in the presence of competing secreted antibodies. Within the tested mechanisms, only clonal competition for T cell help or a refractory time for the interaction of centrocytes with follicular dendritic cells is found to enable affinity maturation while generating the experimentally observed germinal centre characteristics and tolerating large variations in the initial antigen density.

Item Type:Article
Uncontrolled Keywords:germinal centre; lymphocytes; B cell selection
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:315
Deposited By:Philip Maini
Deposited On:07 Nov 2006
Last Modified:20 Jul 2009 14:20

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