The Mathematical Institute, University of Oxford, Eprints Archive

Multiscale modelling of tumour growth and therapy: the influence of vessel normalisation on chemotherapy

Alarcon, T. and Owen, M. R. and Byrne, H. M. and Maini, P. K. (2006) Multiscale modelling of tumour growth and therapy: the influence of vessel normalisation on chemotherapy. Computational & Mathematical Methods in Medicine, 7 (2-3). pp. 85-119.

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Abstract

Following the poor clinical results of antiangiogenic drugs, particularly when applied in isolation, tumour biologists and clinicians are now turning to combinations of therapies in order to obtain better results. One of these involves vessel normalisation strategies. In this paper, we investigate the effects on tumour growth of combinations of antiangiogenic and standard cytotoxic drugs, taking into account vessel normalisation. An existing multiscale framework is extended to include new elements such as tumour-induced vessel dematuration. Detailed simulations of our multiscale framework allow us to suggest one possible mechanism for the observed vessel normalisation-induced improvement in the efficacy of cytotoxic drugs: vessel dematuration produces extensive regions occupied by quiescent (oxygen-starved) cells which the cytotoxic drug fails to kill. Vessel normalisation reduces the size of these regions, thereby allowing the chemotherapeutic agent to act on a greater number of cells.

Item Type:Article
Uncontrolled Keywords:Hybrid cellular automaton, VEGF, Vessel dematuration, Antiangiogenic therapy
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:313
Deposited By:Philip Maini
Deposited On:07 Nov 2006
Last Modified:20 Jul 2009 14:20

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