The Mathematical Institute, University of Oxford, Eprints Archive

A filter-flow perspective of haematogenous metastasis offers a non-genetic paradigm for personalised cancer therapy

Scott, J G and Fletcher, A G and Maini, P. K. and Anderson, A R A and Baker, R. E. (2014) A filter-flow perspective of haematogenous metastasis offers a non-genetic paradigm for personalised cancer therapy. European Journal of Cancer, 50 (17). pp. 3068-3075.

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Abstract

Research into mechanisms of haematogenous metastasis has largely become genetic in focus, attempting to understand the molecular basis of ‘seed–soil’ relationships. Preceding this biological mechanism is the physical process of dissemination of circulating tumour cells (CTCs) in the circulation. Patterns of metastatic spread have been previously quantified using the metastatic efficiency index, a measure quantifying metastatic incidence for a given primary-target organ pair and the relative blood flow between them. We extend this concept to take into account the reduction in CTCs which occurs in organ capillary beds connected by a realistic vascular network topology. Application to a dataset of metastatic incidence reveals that metastatic patterns depend strongly on assumptions about the existence and location of micrometastatic disease which governs CTC dynamics on the network, something which has heretofore not been considered – an oversight which precludes our ability to predict metastatic patterns in individual patients.

Item Type:Article
Uncontrolled Keywords:Mathematical model; Metastasis; Oligometastasis; Circulating tumour cells
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:1867
Deposited By: Philip Maini
Deposited On:30 Oct 2014 08:52
Last Modified:29 May 2015 19:33

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