The Mathematical Institute, University of Oxford, Eprints Archive

An ordinary differential equation model for full thickness wounds and the effects of diabetes

Bowden, L G and Maini, P K and Moulton, D E and Tang, J B and Wang, X T and Liu, P Y and Byrne, H M (2014) An ordinary differential equation model for full thickness wounds and the effects of diabetes. Journal of Theoretical Biology, 361 (1). pp. 87-100.

[img]
Preview
PDF
900kB

Abstract

Wound healing is a complex process in which a sequence of interrelated phases contributes to a reduction in wound size. For diabetic patients, many of these processes are compromised, so that wound healing slows down. In this paper we present a simple ordinary differential equation model for wound healing in which attention focusses on the dominant processes that contribute to closure of a full thickness wound. Asymptotic analysis of the resulting model reveals that normal healing occurs in stages: the initial and rapid elastic recoil of the wound is followed by a longer proliferative phase during which growth in the dermis dominates healing. At longer times, fibroblasts exert contractile forces on the dermal tissue, the resulting tension stimulating further dermal tissue growth and enhancing wound closure. By fitting the model to experimental data we find that the major difference between normal and diabetic healing is a marked reduction in the rate of dermal tissue growth for diabetic patients. The model is used to estimate the breakdown of dermal healing into two processes: tissue growth and contraction, the proportions of which provide information about the quality of the healed wound. We show further that increasing dermal tissue growth in the diabetic wound produces closure times similar to those associated with normal healing and we discuss the clinical implications of this hypothesised treatment.

Item Type:Article
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:1854
Deposited By: Philip Maini
Deposited On:16 Aug 2014 09:03
Last Modified:29 May 2015 19:33

Repository Staff Only: item control page