The Mathematical Institute, University of Oxford, Eprints Archive

Increased expression of phosphorrylated NBS1, a key molecule of the DNA damage response machinery, is an adverse prognostic factor in patients with de novo myelodysplastic syndromes

Kefala, M and Papageorgiou, S G and Kontos, C K and Economopoulou, P and Tsanas, A and Panayiotides, I G and Gorgoulis, V G and Patsouris, E and Foukas, P G (2013) Increased expression of phosphorrylated NBS1, a key molecule of the DNA damage response machinery, is an adverse prognostic factor in patients with de novo myelodysplastic syndromes. Leukemia Research, 37 (11). pp. 1576-1582.

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Abstract

The expression of activated forms of key proteins of the DNA damage response machinery (pNBS1, pATM and γH2AX) was assessed by means of immunohistochemistry in bone marrow biopsies of 74 patients with de novo myelodysplastic syndromes (MDS) and compared with 15 cases of de novo acute myeloid leukemia (AML) and 20 with reactive bone marrow histology. Expression levels were significantly increased in both MDS and AML, compared to controls, being higher in high-risk than in low-risk MDS. Increased pNBS1 and γH2AX expression possessed a significant negative prognostic impact for overall survival in MDS patients, whereas pNBS1 was an independent marker of poor prognosis.

Item Type:Article
Uncontrolled Keywords:Myelodysplastic syndromes; DNA damage response; pNBS1; pATM; γH2AX
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:1815
Deposited By: Sara Jolliffe
Deposited On:28 Feb 2014 10:07
Last Modified:29 May 2015 19:30

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