The Mathematical Institute, University of Oxford, Eprints Archive

Mechanisms and mechanics of cell competition in epithelia

Vincent, J P and Fletcher, A G and Baena-Lopez, L A (2013) Mechanisms and mechanics of cell competition in epithelia. Nature Review Molecular Cellular Biology, 14 (9). pp. 581-591.

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Abstract

When fast-growing cells are confronted with slow-growing cells in a mosaic tissue, the slow-growing cells are often progressively eliminated by apoptosis through a process known as cell competition. The underlying signalling pathways remain unknown, but recent findings have shown that cell crowding within an epithelium leads to the eviction of cells from the epithelial sheet. This suggests that mechanical forces could contribute to cell elimination during cell competition.

Item Type:Article
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:1777
Deposited By: Sara Jolliffe
Deposited On:12 Feb 2014 08:50
Last Modified:29 May 2015 19:28

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