The Mathematical Institute, University of Oxford, Eprints Archive

Fractional diffusion models of cardiac electrical propagation: role of structural heterogeneity in dispersion of repolarization

Bueno-Orovio, A. and Kay, D. and Grau, V. and Rodriguez, B. and Burrage, K. (2013) Fractional diffusion models of cardiac electrical propagation: role of structural heterogeneity in dispersion of repolarization. Nature Communications . (Submitted)

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Abstract

Structural heterogeneity constitutes one of the main substrates influencing impulse propagation in living tissues. In cardiac muscle, improved understanding on its role is key to advancing our interpretation of cell-to-cell coupling, and how tissue structure modulates electrical propagation and arrhythmogenesis in the intact and diseased heart. We propose fractional diffusion models as a novel mathematical description of structurally heterogeneous excitable media, as a mean of representing the modulation of the total electric field by the secondary electrical sources associated with tissue inhomogeneities. Our results, validated against in-vivo human recordings and experimental data of different animal species, indicate that structural heterogeneity underlies many relevant characteristics of cardiac propagation, including the shortening of action potential duration along the activation pathway, and the progressive modulation by premature beats of spatial patterns of dispersion of repolarization. The proposed approach may also have important implications in other research fields involving excitable complex media.

Item Type:Article
Subjects:D - G > General
Research Groups:Oxford Centre for Collaborative Applied Mathematics
ID Code:1731
Deposited By: Peter Hudston
Deposited On:30 Jul 2013 13:09
Last Modified:29 May 2015 19:25

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