The Mathematical Institute, University of Oxford, Eprints Archive

Population of human ventricular cell models calibrated with in vivo measurements unravels ionic mechanisms of cardiac alternans

Zhou, X. and Bueno-Orovio, A. and Orini, M. and Hanson, B. and Haywood, M. and Taggart, P. and Lambiase, P. and Burrage, K. and Rodriguez, B. (2013) Population of human ventricular cell models calibrated with in vivo measurements unravels ionic mechanisms of cardiac alternans. In: Computing in Cardiology Conference. (Submitted)

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Abstract

Cardiac alternansis an important risk factor in cardiac physiology, and is related to the initiation of many pathophysiological conditions. However, the mechanisms underlying the generation of alternans remain unclear. In this study, we used a population of computational human ventricle models based onthe O’Hara model [1] to explore the effect of 11 key factors experimentally reported to be related to alternans. In vivo experimental datasets coming from patients undergoing cardiac surgery were used in the calibration of our in silico population of models. The calibrated models in the population were divided into two groups (Normal and Alternans) depending on alternans occurrence. Our results showed that there were significant differences in the following 5 ionic currents between the two groups: fast sodium current, sodium calcium exchanger current, sodium potassium pump current, sarcoplasmic reticulum (SR) calcium release flux and SR calcium reuptake flux. Further analysis indicated that fast sodium current and SR calcium uptake were the two most significant currents that contributed to voltage and calcium alternans generation, respectively.

Item Type:Conference or Workshop Item (Paper)
Subjects:D - G > General
Research Groups:Oxford Centre for Collaborative Applied Mathematics
ID Code:1726
Deposited By: Peter Hudston
Deposited On:30 Jul 2013 13:11
Last Modified:29 May 2015 19:25

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