The Mathematical Institute, University of Oxford, Eprints Archive

A stochastic model for early placental development

Cotter, S. L. and Klika, V. and Kimpton, L.S. and Collins, S.L and Heazell, A. E. P. (2013) A stochastic model for early placental development. Journal of the Royal Society Interface . (Submitted)

[img]
Preview
PDF
527kB

Abstract

In the human, placental structure is closely related to placental function and consequent pregnancy outcome. Studies have noted abnormal placental shape in small-for-gestational age infants which extends to increased lifetime risk of cardiovascular disease. The origins and determinants of placental shape are incompletely under-stood and are difficult to study in vivo. In this paper we model the early development of the placenta in the human, based on the hypothesis that this is driven by dynamics dominated by a chemo-attractant effect emanating from proximal spiral arteries in the decidua. We derive and explore a two-dimensional stochastic model for these events, and investigate the effects of loss of spiral arteries in regions near to the cord insertion on the shape of the placenta. This model demonstrates that placental shape is highly variable and disruption of spiral arteries can exert profound effects on placental shape, particularly if this disruption is close to the cord insertion. Thus, placental shape reflects the underlying maternal vascular bed. Abnormal placental shape may reflect an abnormal uterine environment, which predisposes to pregnancy complications.

Item Type:Article
Subjects:D - G > General
Research Groups:Oxford Centre for Collaborative Applied Mathematics
ID Code:1714
Deposited By: Peter Hudston
Deposited On:30 Jul 2013 13:17
Last Modified:29 May 2015 19:24

Repository Staff Only: item control page