The Mathematical Institute, University of Oxford, Eprints Archive

Multiscale stochastic reaction-diffusion modelling: application to actin dynamics in filopodia

Erban, R. and Flegg, M. B. and Papoian, G. A. (2012) Multiscale stochastic reaction-diffusion modelling: application to actin dynamics in filopodia. Bulletin of Mathematical Biology . (Submitted)

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Abstract

Two multiscale (hybrid) stochastic reaction-diffusion models of actin dynamics in a filopodium are investigated. Both hybrid algorithms combine compartment-based and molecular-based stochastic reaction-diffusion models. The first hybrid model is based on the models previously
developed in the literature. The second hybrid model is based on the application of recently developed two-regime method (TRM) to a fully molecular-based model which is also developed in this paper. The results of hybrid models are compared with the results of the molecular-based model. It is shown that both approaches give comparable results, although the TRM model better agrees quantitatively with the molecular-based model.

Item Type:Article
Subjects:D - G > General
Research Groups:Oxford Centre for Collaborative Applied Mathematics
ID Code:1665
Deposited By: Peter Hudston
Deposited On:09 Feb 2013 09:39
Last Modified:29 May 2015 19:21

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