The Mathematical Institute, University of Oxford, Eprints Archive

Modelling Oscillator synchronisation during vertebrate axis segmentation

Murray, P J and Maini, P. K. and Baker, R. E. (2013) Modelling Oscillator synchronisation during vertebrate axis segmentation. In: Springer Proceedings in Mathematics. Pattern Formation in Morphogenesis, 15 . Springer-Verlag Berlin Heidelberg, Heidelberg, pp. 95-105. ISBN 978-3-642-20164-6

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Abstract

he somitogenesis clock regulates the periodicity with which somites form in the posterior pre-somitic mesoderm. Whilst cell heterogeneity results in noisy oscillation rates amongst constituent cells, synchrony within the population is maintained as oscillators are entrained via juxtracine signalling mechanisms. Here we consider a population of phase-coupled oscillators and investigate how biologically motivated perturbations to the entrained state can perturb synchrony within the population. We find that the ratio of mitosis length to clock period can influence levels of desynchronisation. Moreover, we observe that random cell movement, and hence change of local neighbourhoods, increases synchronisation.

Item Type:Book Section
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:1651
Deposited By: Philip Maini
Deposited On:10 Jan 2013 08:41
Last Modified:29 May 2015 19:20

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