The Mathematical Institute, University of Oxford, Eprints Archive

Colorectal Cancer Through Simulation and Experiment

Kershaw, S. K. and Byrne, H. M. and Gavaghan, D. J. and Osborne, J. M. (2012) Colorectal Cancer Through Simulation and Experiment. IET Systems Biology . (Submitted)



Colorectal cancer has continued to generate a huge amount of research interest over several decades, forming a canonical example of tumourigenesis since its use in Fearon and Vogelstein’s linear model of genetic mutation. Over time, the field has witnessed a transition from solely experimental work to the inclusion of mathematical biology and computer-based modelling. The fusion of these disciplines has the potential to provide valuable insights into oncologic processes, but also presents the challenge of uniting many diverse perspectives. Furthermore, the cancer cell phenotype defined by the ‘Hallmarks of Cancer’ has been extended in recent times and provides an excellent basis for future research. We present a timely summary of the literature relating to colorectal cancer, addressing the traditional experimental findings, summarising the key mathematical and computational approaches, and emphasising the role of the Hallmarks in current and future developments. We conclude with a discussion of interdisciplinary work, outlining areas of experimental interest which would benefit from the insight that mathematical and computational modelling can provide.

Item Type:Article
Subjects:D - G > General
Research Groups:Oxford Centre for Collaborative Applied Mathematics
ID Code:1530
Deposited By: Peter Hudston
Deposited On:04 Jul 2012 08:11
Last Modified:29 May 2015 19:13

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