The Mathematical Institute, University of Oxford, Eprints Archive

A fibrocontractive mechanochemical model of dermal wound closure incorporating realistic growth factor kinetics

Murphy, K. E. and Hall, C. L. and Maini, P. K. and McCue, S. W. and D L Sean, McElwain (2012) A fibrocontractive mechanochemical model of dermal wound closure incorporating realistic growth factor kinetics. Bulletin of Mathematical Biology, 74 (5). pp. 1143-1170. ISSN 0092-8240

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Abstract

Fibroblasts and their activated phenotype, myofibroblasts, are the primary cell types involved in the contraction associated with dermal wound healing. Recent experimental evidence indicates that the transformation from fibroblasts to myofibroblasts involves two distinct processes: The cells are stimulated to change phenotype by the combined actions of transforming growth factor β (TGFβ) and mechanical tension. This observation indicates a need for a detailed exploration of the effect of the strong interactions between the mechanical changes and growth factors in dermal wound healing. We review the experimental findings in detail and develop a model of dermal wound healing that incorporates these phenomena. Our model includes the interactions between TGFβ and collagenase, providing a more biologically realistic form for the growth factor kinetics than those included in previous mechanochemical descriptions. A comparison is made between the model predictions and experimental data on human dermal wound healing and all the essential features are well matched.

Item Type:Article
Uncontrolled Keywords:Biomechanics – Myofibroblasts – Transforming growth factor-β – Contraction
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:1506
Deposited By:Philip Maini
Deposited On:04 Apr 2012 08:16
Last Modified:08 Oct 2012 14:11

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