The Mathematical Institute, University of Oxford, Eprints Archive

Synaptic bistability due to nucleation and evaporation of receptor clusters

Burlakov, V. and Emptage, N. and Goriely, A. and Bressloff, P. C. (2011) Synaptic bistability due to nucleation and evaporation of receptor clusters. Physical Review Letters . (Submitted)

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Abstract

We introduce a bistable mechanism for long-term synaptic plasticity based on switching between two metastable states that contain significantly different numbers of synaptic receptors. One state is characterized by a two-dimensional gas of mobile interacting receptors and is stabilized against clustering by a high nucleation barrier. The other state contains a receptor gas in equilibrium with a large cluster of immobile receptors, which is stabilized from growing further by the turnover rate of receptors into and out of the synapse. Transitions between the two states can be initiated by either an increase (potentiation) or a decrease (depotentiation) of the net receptor flux into the synapse. This changes the saturation level of the receptor gas and triggers nucleation or evaporation of receptor clusters.

Item Type:Article
Subjects:D - G > General
Research Groups:Oxford Centre for Collaborative Applied Mathematics
ID Code:1414
Deposited By:Peter Hudston
Deposited On:08 Nov 2011 09:49
Last Modified:09 Feb 2012 13:59

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