Kelly, S and Wickstead, B and Maini, P. K. and Gull, K (2011) Ab initio identification of novel regulatory elements in the genome of Trypanosma brucei by Bayesioan inference on sequence segmentation. PLOs One, 6 (10). e25666 (11 pages).
The rapid increase in the availability of genome information has created considerable demand for both comparative and ab initio predictive bioinformatic analyses. The biology laid bare in the genomes of many organisms is often novel, presenting new challenges for bioinformatic interrogation. A paradigm for this is the collected genomes of the kinetoplastid parasites, a group which includes Trypanosoma brucei the causative agent of human African trypanosomiasis. These genomes, though outwardly simple in organisation and gene content, have historically challenged many theories for gene expression regulation in eukaryotes.
|Subjects:||A - C > Biology and other natural sciences|
|Research Groups:||Centre for Mathematical Biology|
|Deposited By:||Philip Maini|
|Deposited On:||06 Oct 2011 07:53|
|Last Modified:||06 Oct 2011 07:53|
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