The Mathematical Institute, University of Oxford, Eprints Archive

Ab initio identification of novel regulatory elements in the genome of Trypanosma brucei by Bayesioan inference on sequence segmentation

Kelly, S and Wickstead, B and Maini, P. K. and Gull, K (2011) Ab initio identification of novel regulatory elements in the genome of Trypanosma brucei by Bayesioan inference on sequence segmentation. PLOs One, 6 (10). e25666 (11 pages).

[img]
Preview
PDF
749Kb

Abstract

The rapid increase in the availability of genome information has created considerable demand for both comparative and ab initio predictive bioinformatic analyses. The biology laid bare in the genomes of many organisms is often novel, presenting new challenges for bioinformatic interrogation. A paradigm for this is the collected genomes of the kinetoplastid parasites, a group which includes Trypanosoma brucei the causative agent of human African trypanosomiasis. These genomes, though outwardly simple in organisation and gene content, have historically challenged many theories for gene expression regulation in eukaryotes.

Item Type:Article
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:1403
Deposited By:Philip Maini
Deposited On:06 Oct 2011 07:53
Last Modified:06 Oct 2011 07:53

Repository Staff Only: item control page