Keener, J. P. and Newby, J. M. (2011) A perturbation analysis of spontaneous action potential initiation by stochastic ion channels. Physical Review E. . (Submitted)

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Abstract
A stochastic interpretation of spontaneous action potential initiation is developed for the Morris Lecar equations. Initiation of a spontaneous action potential can be interpreted as the escape from one of the wells of a double well potential, and we develop an asymptotic approximation of the mean exit time using a recentlydeveloped quasistationary perturbation method. Using the fact that the activating ionic channel’s random openings and closings are fast relative to other processes, we derive an accurate estimate for the mean time to fire an action potential (MFT), which is valid for a belowthreshold applied current. Previous studies have found that for abovethreshold applied current, where there is only a single stable fixed point, a diffusion approximation can be used. We also explore why different diffusion approximation techniques fail to estimate the MFT.
Item Type:  Article 

Subjects:  D  G > General 
Research Groups:  Oxford Centre for Collaborative Applied Mathematics 
ID Code:  1392 
Deposited By:  Peter Hudston 
Deposited On:  09 Sep 2011 06:56 
Last Modified:  29 May 2015 19:05 
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