The Mathematical Institute, University of Oxford, Eprints Archive

Tissue capillary supply - it's quality not quantity that counts!

Egginton, S and Gaffney, E. A. (2010) Tissue capillary supply - it's quality not quantity that counts! Experimental Physiology, 95 (8). pp. 971-979.

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Abstract

This article explores how common misunderstandings about the microcirculation – that capillary supply varies directly with O2 demand, that local capillary supply in muscle is determined by fibre type and that it is appropriate to model capillary distribution as either random or in a fixed geometric pattern – arise from quantifying capillarity by simple measures of quantitative extent, rather than the more functionally relevant qualitative distribution. We show that the latter approach reveals exquisite control of angiogenesis that determines the location of new vessels with astonishing accuracy, motivating a reappraisal of the physiological remodelling process and a new approach to computational investigations into peripheral O2 transport.

Item Type:Article
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:1361
Deposited By:Eamonn Gaffney
Deposited On:05 Aug 2011 08:54
Last Modified:05 Aug 2011 08:54

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