The Mathematical Institute, University of Oxford, Eprints Archive

Self-organizing & stochastic behaviors during the regeneration of hair stem cells

Plikus, M. V. and Baker, R. E. and Chen, C C and Fare, C and de La Cruz, D. and Andl, T and Maini, P. K. (2011) Self-organizing & stochastic behaviors during the regeneration of hair stem cells. Science, 332 (6029). p. 586.

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Abstract

Stem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative behavior in a hair follicle population. By combining predictive mathematical modeling with in vivo studies in mice and rabbits, we show that a follicle progresses through cycling stages by continuous integration of inputs from intrinsic follicular and extrinsic environmental signals based on universal patterning principles. Signaling from the WNT/bone morphogenetic protein activator/inhibitor pair is coopted to mediate interactions among follicles in the population. This regenerative strategy is robust and versatile because relative activator/inhibitor strengths can be modulated easily, adapting the organism to different physiological and evolutionary needs.

Item Type:Article
Subjects:A - C > Biology and other natural sciences
Research Groups:Centre for Mathematical Biology
ID Code:1069
Deposited By:Philip Maini
Deposited On:06 May 2011 08:22
Last Modified:06 May 2011 08:22

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