The Mathematical Institute, University of Oxford, Eprints Archive

A theory for the alignment of cortical feature maps during
development

Bressloff, P. C. and Oster, A. M. (2010) A theory for the alignment of cortical feature maps during
development.
Physical Review E . (Submitted)

[img]
Preview
PDF
737Kb

Abstract

We present a developmental model of ocular dominance column formation that takes into account the existence of an array of intrinsically specified cytochrome oxidase blobs. We assume that there is some molecular substrate for the blobs early in development, which generates a spatially periodic modulation of experience–dependent plasticity. We determine the effects of such a modulation on a competitive Hebbian mechanism for the modification of the feedforward afferents from the left and right eyes. We show how alternating left and right eye dominated columns can develop, in which the blobs are aligned with the centers of the ocular dominance columns and receive a greater density of feedforward connections, thus becoming defined extrinsically. More generally, our results suggest that the presence of periodically distributed anatomical markers early in development could provide a mechanism for the alignment of cortical feature maps.

Item Type:Article
Subjects:D - G > General
Research Groups:Oxford Centre for Collaborative Applied Mathematics
ID Code:1015
Deposited By:Peter Hudston
Deposited On:28 Oct 2010 14:33
Last Modified:09 Feb 2012 15:53

Repository Staff Only: item control page